Short-term interruption is generally fine.
Most patients are anti-coagulated for atrial fibrillation or deep vein thrombosis. Why was the patient initially anti-coagulated? Determine what doses of medication the patient is on, and when is the last time a dose was taken. Review all medications the patient is taking which may affect coagulation (including over-the-counter aspirin or aspirin-containing products). In this situation, thromboelastography (TEG) may be more accurate. For patients with cirrhosis or disseminated intravascular coagulation (DIC), traditional coagulation parameters (e.g., INR) don't necessarily reflect the true coagulation state. Consider all medications and coagulation labs in order to get a global sense of how coagulopathic the patient is. 
Critically ill patients often have several coagulopathies (e.g., thrombocytopenia plus supratherapeutic INR on warfarin).
Considerations when approaching anticoagulation reversal
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